Protecting mass and function in older adults during bed rest

Wolfson L, Judge J, Whipple R, King M.
Strength is a major factor in balance, gait, and the occurrence of falls.
J Gerontol A Biol Sci Med Sci. 1995;50:64–67. Spec No. [PubMed] []

Manini TM, Visser M, Won-Park S, et al.
Knee extension strength cutpoints for maintaining mobility.
J Am Geriatr Soc. 2007;55:451–457. [PubMed] []

Baumgartner RN, Koehler KM, Gallagher D, et al.
Epidemiology of sarcopenia among the elderly in New Mexico.
Am J Epidemiol. 1998;147:755–763. [PubMed] []

Covinsky KE, Palmer RM, Fortinsky RH, et al.
Loss of independence in activities of daily living in older adults hospitalized with medical illnesses: increased vulnerability with age.
J Am Geriatr Soc. 2003;51:451–458. [PubMed] []
Brown CJ, Friedkin RJ, Inouye SK.
Prevalence and outcomes of low mobility in hospitalized older patients.
J Am Geriatr Soc. 2004;52:1263–1270. [PubMed] []
Janssen I.
Influence of sarcopenia on the development of physical disability: the Cardiovascular Health Study.
J Am Geriatr Soc. 2006;54:56–62. [PubMed] []
Hirsch CH, Sommers L, Olsen A, et al.
The natural history of functional morbidity in hospitalized older patients.
J Am Geriatr Soc. 1990;38:1296–1303. [PubMed] []
Visser M, Harris TB, Fox KM, et al.
Change in muscle mass and muscle strength after a hip fracture: relationship to mobility recovery.
J Gerontol A Biol Sci Med Sci. 2000;55:M434–440. [PubMed] []

Ferrando AA, Lane HW, Stuart CA, et al.
Prolonged bed rest decreases skeletal muscle and whole body protein synthesis.
Am J
Physiol. 1996;270:E627–633. [PubMed] []

LeBlanc AD, Schneider VS, Evans HJ, et al.
Regional changes in muscle mass following 17 weeks of bed rest.
J Appl Physiol. 1992;73:2172–2178. [PubMed] []
Paddon-Jones D, Sheffield-Moore M, Urban RJ, et al.
Essential amino acid and carbohydrate supplementation ameliorates muscle protein loss in humans during 28 days bedrest.
J Clin Endocrinol Metab. 2004;89:4351–4358. [PubMed] []

Trappe TA, Burd NA, Louis ES, et al.
Influence of concurrent exercise or nutrition countermeasures on thigh and calf muscle size and function during 60 days of bed rest in women.
Acta Physiol (Oxf) 2007;191:147–159. [PubMed] []

Kortebein P, Ferrando A, Lombeida J, et al.
Effect of 10 days of bed rest on skeletal muscle in healthy older adults.
Jama. 2007;297:1772–1774. [PubMed] []

Paddon-Jones D, Sheffield-Moore M, Cree MG, et al.
Atrophy and impaired muscle protein synthesis during prolonged inactivity and stress.
J Clin Endocrinol Metab. 2006;91:4836–4841. [PubMed] []

Symons TB, Sheffield-Moore M, Chinkes DL, et al.
Artificial gravity maintains skeletal muscle protein synthesis during 21 days of simulated microgravity.
J Appl Physiol. 2009;107:34–38. [PMC free article][PubMed] []

Phillips SM, Glover EI, Rennie MJ.
Alterations of protein turnover underlying disuse atrophy in human skeletal muscle.
J Appl Physiol. 2009 Jul. 16 [This review highlights the effects of disuse on muscle protein synthesis and breakdown.] [PubMed] []

Rennie MJ, Selby A, Atherton P, et al.
Facts, noise and wishful thinking: muscle protein turnover in aging and human disuse atrophy.
Scand J Med Sci Sports. 2009 [PubMed] []

Volpi E, Mittendorfer B, Rasmussen BB, Wolfe RR.
The response of muscle protein anabolism to combined hyperaminoacidemia and glucose-induced hyperinsulinemia is impaired in the elderly.
J Clin Endocrinol Metab. 2000;85:4481–4490. [PMC free article] [PubMed] []

Glover EI, Phillips SM, Oates BR, et al.
Immobilization induces anabolic resistance in human myofibrillar protein synthesis with low and high dose amino acid infusion.
J Physiol. 2008;586:6049–6061.[This study showed that, following immobilization, both post-absorptive and post-prandial muscle protein synthesis are reduced, even with high doses of available amino acids.] [PMC free article] [PubMed] []

Visser M, Goodpaster BH, Kritchevsky SB, et al.
Muscle mass, muscle strength, and muscle fat infiltration as predictors of incident mobility limitations in well-functioning older persons.
J Gerontol A Biol Sci Med Sci. 2005;60:324–333. [PubMed] []

Gill TM, Allore H, Guo Z.
The deleterious effects of bed rest among community-living older persons.
J Gerontol A Biol Sci Med Sci. 2004;59:755–761. [PubMed] []

Kortebein P, Symons TB, Ferrando A, et al.
Functional impact of 10 days of bed rest in healthy older adults.
J Gerontol A Biol Sci Med Sci. 2008;63:1076–1081.[This is the first study to report functional performance measures in a controlled bed rest study with elderly subjects.] [PubMed] []

Sager MA, Franke T, Inouye SK, et al.
Functional outcomes of acute medical illness and hospitalization in older persons.
Arch Intern Med. 1996;156:645–652. [PubMed] []

Counsell SR, Holder CM, Liebenauer LL, et al.
Effects of a multicomponent intervention on functional outcomes and process of care in hospitalized older patients: a randomized controlled trial of Acute Care for Elders (ACE) in a community hospital.
J Am Geriatr Soc. 2000;48:1572–1581. [PubMed] []

Beckers PJ, Denollet J, Possemiers NM, et al.
Combined endurance-resistance training vs. endurance training in patients with chronic heart failure: a prospective randomized study.
Eur Heart J. 2008;29:1858–1866. [PubMed] []

Beyer N, Simonsen L, Bulow J, et al.
Old women with a recent fall history show improved muscle strength and function sustained for six months after finishing training.
Aging Clin Exp Res. 2007;19:300–309. [PubMed] []

Deley G, Kervio G, Van Hoecke J, et al.
Effects of a one-year exercise training program in adults over 70 years old: a study with a control group.
Aging Clin Exp Res. 2007;19:310–315. [PubMed] []

Fiatarone MA, Marks EC, Ryan ND, et al.
High-intensity strength training in nonagenarians. Effects on skeletal muscle.
Jama. 1990;263:3029–3034. [PubMed] []

Fiatarone MA, O’Neill EF, Ryan ND, et al.
Exercise training and nutritional supplementation for physical frailty in very elderly people.
N Engl J Med. 1994;330:1769–1775. [PubMed] []

Fielding RA, LeBrasseur NK, Cuoco A, et al.
High-velocity resistance training increases skeletal muscle peak power in older women.
J Am Geriatr Soc. 2002;50:655–662. [PubMed] []

Henwood TR, Taaffe DR.
Short-term resistance training and the older adult: the effect of varied programmes for the enhancement of muscle strength and functional performance.
Clin Physiol Funct Imaging. 2006;26:305–313. [PubMed] []

Kryger AI, Andersen JL.
Resistance training in the oldest old: consequences for muscle strength, fiber types, fiber size, and MHC isoforms.
Scand J Med Sci Sports. 2007;17:422–430. [PubMed] []

Suetta C, Andersen JL, Dalgas U, et al.
Resistance training induces qualitative changes in muscle morphology, muscle architecture, and muscle function in elderly postoperative patients.
J Appl Physiol. 2008;105:180–186. [PubMed] []

Morse CI, Thom JM, Mian OS, et al.
Gastrocnemius specific force is increased in elderly males following a 12-month physical training programme.
Eur J Appl Physiol. 2007;100:563–570. [PubMed] []

Phillips SM, Tipton KD, Aarsland A, et al.
Mixed muscle protein synthesis and breakdown after resistance exercise in humans.
Am J Physiol. 1997;273:E99–107. [PubMed] []

Phillips SM, Tipton KD, Ferrando AA, Wolfe RR.
Resistance training reduces the acute exercise-induced increase in muscle protein turnover.
Am J Physiol. 1999;276:E118–124. [PubMed] []

Trappe S, Costill D, Gallagher P, et al.
Exercise in space: human skeletal muscle after 6 months aboard the International Space Station.
J Appl Physiol. 2009;106:1159–1168.[This study provides a comprehensive report on calf muscle adaptations following 6 mo of unloading on the International Space Station.] [PubMed] []

Shackelford LC, LeBlanc AD, Driscoll TB, et al.
Resistance exercise as a countermeasure to disuse-induced bone loss.
J Appl Physiol. 2004;97:119–129. [PubMed] []

Caiozzo VJ, Haddad F, Lee S, et al.
Artificial gravity as a countermeasure to microgravity: a pilot study examining the effects on knee extensor and plantar flexor muscle groups.
J Appl Physiol. 2009;107:39–46.[PMC free article] [PubMed] []

Gibson JN, Smith K, Rennie MJ.
Prevention of disuse muscle atrophy by means of electrical stimulation: maintenance of protein synthesis.
Lancet. 1988;2:767–770. [PubMed] []

DiMaria-Ghalili RA, Bankhead R, Fisher AA, et al.
Standards of practice for nutrition support nurses.
Nutr Clin Pract. 2007;22:458–465. [PubMed] []

Mikkelsen BE, Beck AM, Lassen A.
Do recommendations for institutional food service result in better food service? A study of compliance in Danish hospitals and nursing homes from 1995 to 2002-2003.
Eur J Clin Nutr. 2007;61:129–134. [PubMed] []

Rasmussen HH, Kondrup J, Ladefoged K, Staun M.[Clinical nutrition in Danish hospitals. A questionnaire study among physicians and nurses].
Ugeskr Laeger. 2000;162:3855–3860. [PubMed] []

Sullivan DH, Sun S, Walls RC.
Protein-energy undernutrition among elderly hospitalized patients: a prospective study.
Jama. 1999;281:2013–2019. [PubMed] []

Houston DK, Nicklas BJ, Ding J, et al.
Dietary protein intake is associated with lean mass change in older, community-dwelling adults: the Health, Aging, and Body Composition (Health ABC) Study.
Am J Clin Nutr. 2008;87:150–155. [PubMed] []

Pepersack T, Corretge M, Beyer I, et al.
Examining the effect of intervention to nutritional problems of hospitalised elderly: a pilot project.
J Nutr Health Aging. 2002;6:306–310. [PubMed] []

Wolfe RR, Miller SL.
The recommended dietary allowance of protein: a misunderstood concept.
Jama. 2008;299:2891–2893. [PubMed] []

Wolfe RR, Miller SL, Miller KB.
Optimal protein intake in the elderly.
Clin Nutr. 2008;27:675–684.[PubMed] []

Paddon-Jones D, Rasmussen BB.
Dietary protein recommendations and the prevention of sarcopenia.
Curr Opin Clin Nutr Metab Care. 2009;12:86–90. [PMC free article] [PubMed] []

Cuthbertson D, Smith K, Babraj J, et al.
Anabolic signaling deficits underlie amino acid resistance of wasting, aging muscle.
Faseb J. 2005;19:422–424. [PubMed] []

Katsanos CS, Kobayashi H, Sheffield-Moore M, et al.
Aging is associated with diminished accretion of muscle proteins after the ingestion of a small bolus of essential amino acids.
Am J Clin Nutr. 2005;82:1065–1073. [PubMed] []

Paddon-Jones D, Sheffield-Moore M, Zhang XJ, et al.
Amino acid ingestion improves muscle protein synthesis in the young and elderly.

Am J Physiol Endocrinol Metab. 2004;286:E321–328. [PubMed] []

Symons TB, Schutzler SE, Cocke TL, et al.
Aging does not impair the anabolic response to a protein-rich meal.
Am J Clin Nutr. 2007;86:451–456. [PubMed] []

Ferrando AA, Paddon-Jones D, Hays NP, et al.
EAA supplementation to increase nitrogen intake improves muscle function during bed rest in the elderly.
Clin Nutr. 2009 May 4;[This is the first study to examine the effect of essential amino acid supplementation in the elderly during experimental bed rest.] [PubMed] []

Brooks N, Cloutier GJ, Cadena SM, et al.
Resistance training and 
] timed essential amino acids protect against the loss of muscle mass and strength during 28 days of bed rest and energy deficit.
J Appl Physiol. 2008;105:241–248. [PMC free article] [PubMed] [

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