Protecting mass and function in older adults during bed rest
Trappe TA, Burd NA, Louis ES, et al.
Influence of concurrent exercise or nutrition countermeasures on thigh and calf muscle size and function during 60 days of bed rest in women.
Acta Physiol (Oxf) 2007;191:147–159. [PubMed] [Google Scholar]
Paddon-Jones D, Sheffield-Moore M, Cree MG, et al.
Atrophy and impaired muscle protein synthesis during prolonged inactivity and stress.
J Clin Endocrinol Metab. 2006;91:4836–4841. [PubMed] [Google Scholar]
Symons TB, Sheffield-Moore M, Chinkes DL, et al.
Artificial gravity maintains skeletal muscle protein synthesis during 21 days of simulated microgravity.
J Appl Physiol. 2009;107:34–38. [PMC free article][PubMed] [Google Scholar]
Phillips SM, Glover EI, Rennie MJ.
Alterations of protein turnover underlying disuse atrophy in human skeletal muscle.
J Appl Physiol. 2009 Jul. 16 [This review highlights the effects of disuse on muscle protein synthesis and breakdown.] [PubMed] [Google Scholar]
Volpi E, Mittendorfer B, Rasmussen BB, Wolfe RR.
The response of muscle protein anabolism to combined hyperaminoacidemia and glucose-induced hyperinsulinemia is impaired in the elderly.
J Clin Endocrinol Metab. 2000;85:4481–4490. [PMC free article] [PubMed] [Google Scholar]
Glover EI, Phillips SM, Oates BR, et al.
Immobilization induces anabolic resistance in human myofibrillar protein synthesis with low and high dose amino acid infusion.
J Physiol. 2008;586:6049–6061.[This study showed that, following immobilization, both post-absorptive and post-prandial muscle protein synthesis are reduced, even with high doses of available amino acids.] [PMC free article] [PubMed] [Google Scholar]
Visser M, Goodpaster BH, Kritchevsky SB, et al.
Muscle mass, muscle strength, and muscle fat infiltration as predictors of incident mobility limitations in well-functioning older persons.
J Gerontol A Biol Sci Med Sci. 2005;60:324–333. [PubMed] [Google Scholar]
Kortebein P, Symons TB, Ferrando A, et al.
Functional impact of 10 days of bed rest in healthy older adults.
J Gerontol A Biol Sci Med Sci. 2008;63:1076–1081.[This is the first study to report functional performance measures in a controlled bed rest study with elderly subjects.] [PubMed] [Google Scholar]
Counsell SR, Holder CM, Liebenauer LL, et al.
Effects of a multicomponent intervention on functional outcomes and process of care in hospitalized older patients: a randomized controlled trial of Acute Care for Elders (ACE) in a community hospital.
J Am Geriatr Soc. 2000;48:1572–1581. [PubMed] [Google Scholar]
Beckers PJ, Denollet J, Possemiers NM, et al.
Combined endurance-resistance training vs. endurance training in patients with chronic heart failure: a prospective randomized study.
Eur Heart J. 2008;29:1858–1866. [PubMed] [Google Scholar]
Beyer N, Simonsen L, Bulow J, et al.
Old women with a recent fall history show improved muscle strength and function sustained for six months after finishing training.
Aging Clin Exp Res. 2007;19:300–309. [PubMed] [Google Scholar]
Deley G, Kervio G, Van Hoecke J, et al.
Effects of a one-year exercise training program in adults over 70 years old: a study with a control group.
Aging Clin Exp Res. 2007;19:310–315. [PubMed] [Google Scholar]
Henwood TR, Taaffe DR.
Short-term resistance training and the older adult: the effect of varied programmes for the enhancement of muscle strength and functional performance.
Clin Physiol Funct Imaging. 2006;26:305–313. [PubMed] [Google Scholar]
Kryger AI, Andersen JL.
Resistance training in the oldest old: consequences for muscle strength, fiber types, fiber size, and MHC isoforms.
Scand J Med Sci Sports. 2007;17:422–430. [PubMed] [Google Scholar]
Suetta C, Andersen JL, Dalgas U, et al.
Resistance training induces qualitative changes in muscle morphology, muscle architecture, and muscle function in elderly postoperative patients.
J Appl Physiol. 2008;105:180–186. [PubMed] [Google Scholar]
Morse CI, Thom JM, Mian OS, et al.
Gastrocnemius specific force is increased in elderly males following a 12-month physical training programme.
Eur J Appl Physiol. 2007;100:563–570. [PubMed] [Google Scholar]
Trappe S, Costill D, Gallagher P, et al.
Exercise in space: human skeletal muscle after 6 months aboard the International Space Station.
J Appl Physiol. 2009;106:1159–1168.[This study provides a comprehensive report on calf muscle adaptations following 6 mo of unloading on the International Space Station.] [PubMed] [Google Scholar]
Caiozzo VJ, Haddad F, Lee S, et al.
Artificial gravity as a countermeasure to microgravity: a pilot study examining the effects on knee extensor and plantar flexor muscle groups.
J Appl Physiol. 2009;107:39–46.[PMC free article] [PubMed] [Google Scholar]
Mikkelsen BE, Beck AM, Lassen A.
Do recommendations for institutional food service result in better food service? A study of compliance in Danish hospitals and nursing homes from 1995 to 2002-2003.
Eur J Clin Nutr. 2007;61:129–134. [PubMed] [Google Scholar]
Houston DK, Nicklas BJ, Ding J, et al.
Dietary protein intake is associated with lean mass change in older, community-dwelling adults: the Health, Aging, and Body Composition (Health ABC) Study.
Am J Clin Nutr. 2008;87:150–155. [PubMed] [Google Scholar]
Pepersack T, Corretge M, Beyer I, et al.
Examining the effect of intervention to nutritional problems of hospitalised elderly: a pilot project.
J Nutr Health Aging. 2002;6:306–310. [PubMed] [Google Scholar]
Katsanos CS, Kobayashi H, Sheffield-Moore M, et al.
Aging is associated with diminished accretion of muscle proteins after the ingestion of a small bolus of essential amino acids.
Am J Clin Nutr. 2005;82:1065–1073. [PubMed] [Google Scholar]
Paddon-Jones D, Sheffield-Moore M, Zhang XJ, et al.
Amino acid ingestion improves muscle protein synthesis in the young and elderly.
Am J Physiol Endocrinol Metab. 2004;286:E321–328. [PubMed] [Google Scholar]
EAA supplementation to increase nitrogen intake improves muscle function during bed rest in the elderly.